Research in Endocrinology




Research Article
Serum-Prolactin and the Association to Disease Activity in Patients with Rheumatoid Arthritis

Hans-Jacob Haga1, Alicia Martin Moreno2, Dorte Terp Andersen3 and Elisabeth Peen1

1Aalborg University Esbjerg, 6700 Esbjerg, Denmark

2Department of urology, The National Hospital, Copenhagen, Denmark

3Clinical molecular diagnostic laboratory, Sydvestjysk sygehus, Esbjerg, Denmark



Volume 2014 (2014), Article ID 396352, Research in Endocrinology, 6 pages, DOI: 10.5171/2014.396352

Received Date: 11 November 2013; Accepted Date: 25 March 2014; Published Date: 29 April 2014

Academic Editor: Athina Pyrpasopoulou


Cite this Article as: Hans-Jacob Haga, Alicia Martin Moreno, Dorte Terp Andersen and Elisabeth Peen (2014), "Serum-Prolactin and the Association to Disease Activity in Patients with Rheumatoid Arthritis," Research in Endocrinology, Vol. 2014 (2014), Article ID 396352, DOI: 10.5171/2014.396352


Copyright © 2014 Hans-Jacob Haga, Alicia Martin Moreno, Dorte Terp Andersen and Elisabeth Peen. Distributed under Creative Commons CC-BY 3.0


Abstract

The objective of this article is to analyze the serum level of Prolactin (s-PRL) in 307 treated patients with Rheumatoid Arthritis (RA), and its association to disease activity, demographics, serological and clinical variables.

The hypothesis to be tested: s-PRL correlates to disease activity in RA.

Serum concentration of the hormone Prolactin (s-PRL) was determined in 307 treated patients with (RA) in a cross-sectional study design.  The patients were characterized by demographic, serological and clinical variables, in addition to assessment of disease activity by DAS28 (3w-CRP) score. Prolactin was analyzed by a double sandwich immune analysis.

Among the 307 RA-patients examined, only 4 patients had high s- PRL defined as females > 637 mIU/L, and males > 456 mIU/L.  These 4 patients all had low disease activity score (DAS 28 score < 2, 0).  There was no correlation of s-PRL to DAS28 score (r= - 0, 08, p=0.21), and no correlation of s-PRL to the number of swollen or tender joints, pain, CRP, Rheumatoid factor or anti-CCP.

We demonstrated that 4 out of 307 RA patients had high level of s-PRL, all of them with low disease activity score.  No correlation of s-PRL to disease activity DAS 28 score was demonstrated. We therefore question the hypothesis that PRL may play a role in disease severity and the development of rheumatoid arthritis.


Keywords: Prolactin, Rheumatoid arthritis, disease activity.
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